Causality assessment: Which is best-expert opinion or RUCAM?

Diagnosing early or rheumatoid arthritis. Which is better: expert opinion or evidence?

Ramadan fasting: Evidence or expert opinion? Results of preliminary studies

Each year, over a billion Muslims fast worldwide during the month of Ramadan.  Through this religious practice, not only will one have spiritual growth, but can improve his/her diet, which is of pivotal importance in this month. Conversely, the available evidence regarding the health benefits of Ramadan fasting is scarce and highly contentious. Although Islam exempts patients from fasting, many...

Causality assessment in drug-induced liver injury using a structured expert opinion process: comparison to the Roussel-Uclaf causality assessment method.

UNLABELLED Drug-induced liver injury (DILI) is largely a diagnosis of exclusion and is therefore challenging. The US Drug-Induced Liver Injury Network (DILIN) prospective study used two methods to assess DILI causality: a structured expert opinion process and the Roussel-Uclaf Causality Assessment Method (RUCAM). Causality assessment focused on detailed clinical and laboratory data from patient...

Methods of Teaching Electrocardiogram: Which One Is the Best?

Introduction: There are many methods for teaching ECG interpretation, but deciding on the best method is yet to be discussed. The purpose of this research was to examine teaching methods for ECG interpretation and introduce the most effective ones. Methods: This systematic review was conducted by searching through scientific databases of PUBMED, Science Direct, SID and IranMedex. Papers publish...

Causality Assessment for Suspected DILI During Clinical Phases of Drug Development

Causality assessment is a critical step in establishing the diagnosis of drug induced liver injury (DILI) during drug development. DILI may resemble almost any type of liver disease, and often presents a serious challenge to clinical investigators and drug makers. The diagnosis of DILI is largely based upon a combination of a compatible clinical course, exclusion of all other reasonable causes,...